ABSTRACT
PURPOSE: To investigate the influence of corneal biomechanical factors on ocular pulse amplitude measured using dynamic contour tonometry in normal subjects. METHODS: The study population consisted of normal subjects who visited the outpatient clinic from January, 2014 to July, 2014. Ocular pulse amplitude was measured using dynamic contour tonometry and corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using an ocular response analyzer. We applied univariate and multivariate linear regressions to investigate the relationship between ocular pulse amplitude and corneal biomechanical factors and other ocular factors. RESULTS: Fifty eyes of 50 patients (average age 52.8 +/- 17.2 years) were examined. The average ocular pulse amplitude was 2.90 +/- 1.04 mm Hg and the CH and CRF were 10.44 +/- 1.96 mm Hg and 11.03 +/- 2.21 mm Hg, respectively. In univariate linear regression, factors influencing ocular pulse amplitude were ocular pressure based on CRF (beta = 0.280, p = 0.049), Goldmann applanation tonometry (beta = 0.293, p = 0.039), and spherical equivalent (beta = 0.283, p = 0.047), while in multivariate linear regression the only factor influencing ocular pulse amplitude was CRF (beta = 0.686, p = 0.042). CONCLUSIONS: A positive correlation between ocular pulse amplitude reflecting ocular perfusion pressure and CRF reflecting corneal elasticity was observed. Correlations between the 2 factors will be an important aspect in future studies regarding the influences of corneal biomechanical factors on ocular perfusion pressure in glaucoma patients.
Subject(s)
Humans , Ambulatory Care Facilities , Elasticity , Glaucoma , Linear Models , Manometry , PerfusionABSTRACT
The malignant peripheral nerve sheath tumor is a rare neoplasm arising from the neural sheath of peripheral nerve sheath, accounting for less than 5% of all soft tissue malignancy. Most tumors occur in patients with neurofibromatosis and solitary malignant peripheral nerve sheath tumor without neurofibromatosis is rare. A review of the literature revealed that there were relatively few documeted cases of these tumors involving digits, although there were several cases of these tumors involving the major peripheral nerve trunk. We report a case of solitary malignant peripheral nerve sheath tumor on a finger, which neither originated from the major peripheral nerve nor was associated with neurofibromatosis. A 46-year-old woman showed a solitary, child palm-sized, eroded fungating tumor on her right third finger tip. Immunohistochemical studies for S-100, neuron-specific enolase, vimentin and electron microscopy were used in the diagnosis, confirming the neural origin of this tumor.
Subject(s)
Child , Female , Humans , Middle Aged , Cytochrome P-450 CYP1A1 , Diagnosis , Fingers , Microscopy, Electron , Neurofibromatoses , Neurofibromatosis 1 , Peripheral Nerves , Phosphopyruvate Hydratase , VimentinABSTRACT
Clear cell basal cell carcinoma (clear cell BCC) is a rare variant of BCC, which is characterized by variable proliferation of clear cells within the mass. We herein report three cases of clear cell BCC. Three old Korean men presented lesions as a solitary nodule on their face. Histologic examination showed multiple dermal tumor lobules composed of basophilic cells, clear cells and peripheral palisading with surrounding retraction spaces. The clear cells showed either a clear cytoplasm or eosinophilic granular cytoplasm, and contained glycogen. There were no recurrences after surgical excision.
Subject(s)
Humans , Male , Basophils , Carcinoma, Basal Cell , Cytoplasm , Eosinophils , Glycogen , RecurrenceABSTRACT
Squamous cell carcinoma of the skin arises mostly in the head and neck regions, less frequently in the rest of the body, and rarely in the palms and soles. We report a case of a 6S-year-old man who had had time-sequential development of multiple squamous cell carcinomas on his palms and soles for the past 12 years. These lesions were, in order of time, ulcerative nodules, ulcerative hyperkeratotic papules, hyperkeratotic plaques, maceratied plaques, dark discolored patchs, and hyperkeratotic papules. They were treated by total excision and cryotherpy apart from the last squatnous cell carcinoma in 1994.